By John Hewitt | @jhewitt123 -
There’s a lot of great medicines out there that don’t work for the brain. That’s primarily because they aren’t membrane-soluble and therefore can’t penetrate the blood brain barrier (BBB) that surrounds its vasculature. For things like cancer or infection, the only way in is to tap into the spine for a one-shot charge, or put in a more permanent indwelling tube that in-and-of itself can lead to further infection.
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Ref: Remote control of the permeability of the blood–brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery. Journal of Controlled Release (2015) | DOI:10.1016/j.jconrel.2015.02.027