A multi-institutional team spanning Baylor College of Medicine, Rice University, Stanford University, and the Broad Institute of MIT and Harvard has reported the first successful genome surgery, changing how the genome is folded inside the nucleus.
The advance may lead to new methods of understanding and overcoming genetic diseases.
Last year, researchers at Baylor College of Medicine’s Center for Genome Architecture demonstrated that when the 2-meter long human genome folds up inside the nucleus of a cell, it forms roughly 10,000 loops.
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