New research reveals how the most common cause of severe allergic reactions to cats, the Fel d 1 protein which is found in cat dander, triggers an allergic response.
Scientists have discovered that when the cat protein Fel d 1 is in the presence of very low doses of the ubiquitous environmental bacterial toxin, lipopolysaccharide (LPS), it activates the pathogen recognition receptor Toll-like receptor 4. Until now, it was not understood how Fel d 1 generated such a large inflammatory response in the immune system.
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